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KMID : 0357920050390050301
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Korean Journal of Pathology
2005 Volume.39 No. 5 p.301 ~ p.306
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Expressions of E2F4 and E2F2 Transcription Factors in Breast Carcinoma
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Kim Eun-Young
Lee Mi-Ja
Jo Hyun-Jin
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Abstract
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Background: The E2F family (E2F1 to E2F6) of transcription factors plays a key role in cell cycle progression. Some act as oncogenes and others act as tumor suppressor genes (TSG) in a tissue-specific manner. E2F4 may function as a TSG. However, the role of E2F4 in breast carcinogenesis remains controversial. Also the clinical impact of E2F2 expression on breast cancer remains unknown.
Methods: Expressions of E2F4 and E2F2 were assessed imunohistochemically in 113 breast carcinomas and were compared with clinicopathological variables, expressions of G1/S checkpoint proteins (p16, cyclin D1 and Rb), and DNA ploidy to identify their possible role and to assess their prognostic value in breast cancer.
Results: Expressions of E2F4 and E2F2 were detected in 48 cases (42.5%) and 66 cases (58.4%), respectively. Expressions of E2F4 and E2F2 were significantly correlated with large tumor size (p<0.001) and lymph node metastasis (p<0.001). There was no correlation between expressions of E2F4 or E2F2 and any other variables, including age, histologic grade, DNA ploidy and expressions of p16, cyclin D1 and Rb.
Conclusions: These results suggest that expressions of E2F4 and E2F2 are associated with growth and spread of breast cancer and indicate poor prognosis.
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KEYWORD
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cancer, E2F4 transcription factor, E2F2 transcription factor, Immunohistochemistry
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